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  • Title: [Low activity of antioxidant enzymes in tumor cells as a factor of oxygen dependence of antitumor cytotoxicity of macrophages].
    Author: Borunov EV, Khavalkin IV, Smirnova LP, Shchepetkin IA, Lankin VZ, Vasil'ev NV.
    Journal: Biull Eksp Biol Med; 1989 Aug; 108(8):233-5. PubMed ID: 2804332.
    Abstract:
    The author studied dependence of cytotoxicity of peritoneal macrophages of Wistar rats on the production of active oxygen form (AOF) and activity of antioxidative enzymes in target cells. Low activity of glutathione-peroxidase and glutathione-reductase in K562 cells could be the cause of macrophage cytotoxicity realization along AOF-dependent way.
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