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  • Title: [Immunohistochemical characteristics of chronic erosion of the gastric mucosa].
    Author: Kanonov AV, Nepomniashchikh LM, Predvechnaia IK, Nepomniashchikh GI.
    Journal: Biull Eksp Biol Med; 1989 Aug; 108(8):247-50. PubMed ID: 2804336.
    Abstract:
    By methods of immunohistochemistry, light and electron microscopies gastrobiopsies from regions of acute and chronic erosions and border zones of gastric mucosa were studied in 36 patients with erosive gastritis. There was determined the decrease of amount of IgA-producing cells against a background of the increase of IgG-producing plasmocytes in the zone of mucosal defect. IgG-precipitations and fixation of heterogeneous complement in fibrinoid necrosis of erosive defect were revealed. Mucosal microcirculatory disturbances stipulated by immunocomplex injuries are found to be mosaic. There is given proof of the role of second local immunity disturbances in origin and chronization of erosive defects of gastric mucosa.
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