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  • Title: High chlorpromazine doses and liver function.
    Author: Castro-e-Silva Júnior O, Ceneviva R, Roselino JE.
    Journal: Braz J Med Biol Res; 1989; 22(3):351-3. PubMed ID: 2804470.
    Abstract:
    The aim of the present study was to evaluate the in vivo effect of high chlorpromazine (CPZ) doses on hepatocellular function. Thirty male Wistar rats weighing 200 to 250 g were divided into two groups: control (C, N = 17), injected ip with saline, and CPZ (N = 13), injected ip with high chlorpromazine doses (initial dose of 30 mg/kg body weight followed by daily doses of 10 mg/kg for 7 days). No significant differences in serum levels of alanine-aminotransferase, alkaline phosphatase and bilirubin or in mitochondrial function (activated and basal respiration and mitochondrial respiration control (activated/basal ratio) were detected between the two groups.
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