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  • Title: Chronic ethanol ingestion selectively affects memory modulation in rats.
    Author: Dalmaz C, Fin C, Oliveira CB, Izquierdo I.
    Journal: Braz J Med Biol Res; 1989; 22(3):403-6. PubMed ID: 2804474.
    Abstract:
    Post-training treatment alters memory by different mechanisms. Naloxone enhances memory by antagonism of endogenous beta-endorphin-induced state dependency. Epinephrine facilitates consolidation at low doses and generates state dependency at high doses. Exposure to a session of tones causes retroactive interference through a cognitive effect. The present data show that chronic ethanol ingestion, in rats, inhibited the post-training effect of naloxone and of a high dose of epinephrine on the retention of an inhibitory avoidance task but did not inhibit retrograde interference by a session of tones or retrograde facilitation by a low dose of epinephrine. Therefore, ethanol appears to selectively affect post-training influences related to state dependency.
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