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  • Title: [Ultrastructural and immunocytochemical study on human silent pituitary adenomas].
    Author: Zhou XJ.
    Journal: Zhonghua Yi Xue Za Zhi; 1989 Jun; 69(6):321-3, 24. PubMed ID: 2804750.
    Abstract:
    16 cases of silent pituitary adenomas were studied with immunoelectron microscopy using protein A-gold probes and were subtyped on their ultrastructural appearances and immunocytochemical reactivity. 2 cases were identified as sparsely granulated PRL adenomas, comprising numerous PRL-positive cells. In 2 acidophil stem cell adenomas were detected GH- and PRL-producing cells, though fewer in number. No hormone activity was found in the secretory granules of 3 oncocytomas and 9 undifferentiated cell adenomas. The morphological features of various silent pituitary adenomas are described and their clinical implications are discussed.
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