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  • Title: Comparison of Catabolic Rates of sn-1, sn-2, and sn-3 Fatty Acids in Triacylglycerols Using 13CO2 Breath Test in Mice.
    Author: Beppu F, Kawamatsu T, Yamatani Y, Nagai T, Yoshinaga K, Mizobe H, Yoshida A, Kubo A, Kanda J, Gotoh N.
    Journal: J Oleo Sci; 2017; 66(1):85-91. PubMed ID: 28049928.
    Abstract:
    Fatty acids in triacylglycerols (TAGs) are catabolized after digestion. However, the catabolic rates of the fatty acids at the sn-1, sn-2, and sn-3 positions of TAGs have not been compared. To elucidate the differences, we studied the catabolic rates of 13C-labeled palmitic acid, oleic acid, and capric acid at the sn-1, sn-2, or sn-3 position of TAGs using isotope-ratio mass spectrometry. Specifically, we measured the 13C-to-12C ratio in CO2 (Δ13C (‰)) exhaled by mice. For all analyzed fatty acids, we observed significant differences between sn-2 and other binding positions. In contrast, no significant difference was detected between the sn-1 and sn-3 positions. These results indicated that the catabolic rates of fatty acids are strongly influenced by their positions in TAGs.
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