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  • Title: Synthesis of a Novel IR-822-Met near-infrared probe for in vivo tumor diagnosis.
    Author: Sun C, Zhang H, Du W, Wang B, Ji M.
    Journal: Biotechnol Lett; 2017 Apr; 39(4):491-499. PubMed ID: 28050673.
    Abstract:
    OBJECTIVE: Methionine is a valid target for the treatment of cancer and to achieve in vivo imaging and early diagnosis of tumors, we have synthesized near-infrared (NIR) fluorochrome IR-822-labeled methionine (IR-822-Met). RESULTS: NIR fluorescent dye IR-822 was conjugated with methionine through its amide bond. It had low toxicity to normal cell/tissues. In vitro and in vivo studies demonstrated its high targeting capability to tumors. The results support the potential of using ligand-modified methionine probe for tumor diagnosis and targeted therapy. The probe also exhibited good photostability, and excellent cell membrane permeability. CONCLUSION: IR-822-Met is a promising imaging agent for tumor diagnosis, especially in their early stage.
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