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  • Title: Radiosensitizing hypoxic cells with new 3-nitro-1,2,4-triazole derivatives in vitro and in vivo.
    Author: Nagao Y, Sano S, Ochiai M, Fuji K, Nishimoto S, Kagiya T, Murayama C, Mori T, Shibamoto Y, Sasai K.
    Journal: Chem Pharm Bull (Tokyo); 1989 Jul; 37(7):1951-3. PubMed ID: 2805177.
    Abstract:
    The new regioisomer derivatives 4a-f and 5a-f of 3-nitro-1,2,4-triazole (3-NTR) were synthesized for the development of new radiosensitizers of hypoxic cancer cells for radiotherapy. N(2)-Substituted 3-NTR derivatives 5a-f were stronger radiosensitizers of hypoxic cells in vitro (Chinese hamster V79 cells) than N(1)-substituted 3-NTR derivatives 4a-f, but in vivo they were weaker (SCCVII carcinoma cells inoculated into C3H/He mouse).
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