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  • Title: Reductive biotransformation of 3-oxo bile acids in human blood.
    Author: Goto J, Miura H, Ando M, Nambara T, Makino I.
    Journal: Chem Pharm Bull (Tokyo); 1989 Jul; 37(7):1960-2. PubMed ID: 2805178.
    Abstract:
    7 alpha,12 alpha-Dihydroxy-3-oxo-5 beta-cholanoic acid labeled with 18O atoms was incubated with human blood, and the biotransformation products were separated and characterized by gas chromatography-mass spectrometry as the pentafluorobenzyl ester-trimethylsilyl and -dimethylethylsilyl ether derivatives. 3 beta,7 alpha,12 alpha-Trihydroxy-5 beta-cholanoic acid was identified as a main metabolite. When 3-oxo bile acid was incubated with human blood denatured at 70 degrees C for 2 min, no metabolites were formed. The enzymic reduction activity proved to be localized in the red blood cell fraction.
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