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  • Title: Prevention of anaphylactoid shock in the rat by the calmodulin antagonist thioridazine.
    Author: Grollmuss O, Sanchez-Delgado E, Bader H.
    Journal: Clin Physiol Biochem; 1989; 7(5):229-37. PubMed ID: 2805571.
    Abstract:
    Calmodulin antagonists, which block intracellular calcium/calmodulin-dependent processes like exocytosis, inhibit effectively mast cell mediator release in vitro. Our experiments confirm that they are also effective in vivo. Thioridazine (5 mg/kg), a representative of the group, prevents the severe anaphylactoid shock in the rat, induced with compound 48/80, and permits a rapid and complete recovery, with special protection of respiration. Thus, calmodulin antagonists seem to be potential drugs for the management of mast cell-mediated allergic diseases.
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