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  • Title: [Value of immunohistochemical investigation of anti-GST-pi antibody in the early diagnosis of gastric carcinoma and precancerous lesion].
    Author: Yin ZZ.
    Journal: Zhonghua Zhong Liu Za Zhi; 1989 Mar; 11(2):114-6. PubMed ID: 2806039.
    Abstract:
    Human placental form of glutathione S-transferase (GST-pi) was detected in 38 human gastric carcinoma and 28 precancerous lesions by Avidin biotin peroxidase complex (ABC) method using anti-GST-pi antibody. Of 22 normal gastric mucosa, 91% were negative for GST-pi stain, 95% of 21 well and moderately differentiated gastric adenocarcinomas, all of 5 poorly differentiated gastric adenocarcinomas, 75% of undifferentiated gastric carcinomas, 85% of intestinal metaplasia and 100% of atypical hyperplasia were positive for GST-pi stain. These results indicate that GST-pi is a new sensitive marker for immunohistochemical detection of gastric carcinoma and precancerous lesion.
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