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  • Title: Isolation of a cDNA encoding the rat liver S-adenosylmethionine synthetase.
    Author: Horikawa S, Ishikawa M, Ozasa H, Tsukada K.
    Journal: Eur J Biochem; 1989 Oct 01; 184(3):497-501. PubMed ID: 2806235.
    Abstract:
    We have isolated cDNA clones encoding the rat liver S-adenosylmethionine synthetase by means of immunological screening from a phage lambda gt 11 expression library containing cDNA synthesized from adult rat liver poly(A)-RNA. The amino acid sequence deduced from the cDNA indicates that the rat liver enzyme for this protein contains 397 amino acid residues and has a molecular mass of 43697 Da. The deduced amino acid sequence of rat liver S-adenosylmethionine synthetase was 68% similar to those of yeast S-adenosylmethionine synthetases encoded by two unlinked genes SAM1 and SAM2. The rat liver S-adenosylmethionine synthetase also shows 52% similarity with the deduced amino acid sequence of the MetK gene encoding the S-adenosylmethionine synthetase in Escherichia coli.
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