These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Differentiated changes in the activity of the sympathetic nerves induced by glycopenia in spontaneously hypertensive rats].
    Author: Medvedev OS, Delle M, Thoren P.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1989 Jul; 75(7):899-903. PubMed ID: 2806664.
    Abstract:
    2-deoxy-D-glucose (2-DG) evokes an increase in the efferent discharge rate of the adrenal nerve in anesthetized rats and rabbits. A 63% increase in adrenal sympathetic nerve activity (adrSNA) occurred within 15 min after 125 mg/kg 2-DG administration in alert animals, no changes being revealed in the renal sympathetic nerve activity (renSNA), blood pressure (BP) or the heart rate (HR). Additional administration of 375 mg/kg 2-DG (cumulative dose 500 mg/kg) led to an over 120% increase in the adrSNA and the 20 mm Hg increase in the BP, whereas renSNA only increased by 30%. These results indicate that 2-DG-induced neuroglycopenia evokes highly differential changes in adrenal and renSNA in alert SHR rats. Whether this explains an obvious response of the BP in SHR to 2-DG, remains to be determined.
    [Abstract] [Full Text] [Related] [New Search]