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  • Title: Iron Overload in the Liver of 2 Children: Nonalcoholic Steatohepatitis and Juvenile Hemochromatosis.
    Author: Ünlüsoy Aksu A, Caleffi A, Pietrangelo A, Sari S, Eğritaş Gürkan Ö, Demirtaş Z, Yilmaz G, Dalgiç B.
    Journal: J Pediatr Hematol Oncol; 2017 Aug; 39(6):466-469. PubMed ID: 28067690.
    Abstract:
    BACKGROUND: Iron overload disorders are hereditary hemochromatosis and secondary etiologies other than hereditary hemochromatosis. We describe 2 boys presenting with iron overload. Juvenile hemochromatosis and nonalcoholic steatohepatitis (NASH) related iron overload are the genetic and secondary causes, respectively. OBSERVATIONS: Both patients benefited from phlebotomy even if they had different etiologies. CONCLUSIONS: In childhood, the diagnosis of iron overload syndromes is crucial because they do not confront us with obvious symptoms and findings. Early initiation of a phlebotomy program can prevent mortality. NASH might lead to iron overload and iron overload might aggravate the clinical course of NASH.
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