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  • Title: Familial Crohn's disease in multiple siblings: no linkage to the HLA system.
    Author: Colombel JF, Guillemot F, Van Gossum A, Dufossé F, Cortot A, Dupont E, Paris JC.
    Journal: Gastroenterol Clin Biol; 1989; 13(8-9):676-8. PubMed ID: 2806803.
    Abstract:
    We report five families with 3 or more children having Crohn's disease. In one family, 6 out of 11 siblings were affected. HLA haplotype study in affected children showed that the probability of random segregation was only 38 percent, making improbable a linkage between the histocompatibility locus and the development of Crohn's disease. However similar clinical patterns in siblings could suggest a genetic factor not linked to the HLA system.
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