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  • Title: A highly selective fluorescent probe for Fe3+ in living cells: a stress induced cell based model study.
    Author: Sharma N, Reja SI, Gupta N, Bhalla V, Kaur D, Arora S, Kumar M.
    Journal: Org Biomol Chem; 2017 Jan 25; 15(4):1006-1012. PubMed ID: 28074954.
    Abstract:
    A rhodamine-phenanthroline dyad based fluorescent probe 4 has been designed and synthesized which selectively monitors Fe3+ ions among the various metal ions tested. Furthermore, probe 4 has been explored for monitoring of dynamic changes in the Fe3+ ion level under aggressive Fenton reaction conditions using a cell based model study. More significantly, probe 4 has also been utilized for real time imaging of endogenous Fe3+ ions in living C6 cell lines, the results of which demonstrated that probe 4 acts as an efficient fluorescent tool for Fe3+ ion detection in biological systems.
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