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  • Title: Thiol Disulfide Homeostasis in Pseudoexfoliation Syndrome.
    Author: Tetikoğlu M, Aktas S, Sağdik HM, Özcura F, Uçar F, Koçak H, Neşelioğlu S, Erel Ö.
    Journal: Curr Eye Res; 2017 Jun; 42(6):876-879. PubMed ID: 28085507.
    Abstract:
    PURPOSE: To determine the serum thiol disulfide homeostasis in patients with pseudoexfoliation (PEX) syndrome. METHOD: Thirty-five patients with PEX syndrome and forty healthy subjects were included in this observational case-control study. Serum native thiol, total thiol, disulfide, and native thiol/disulfide ratio were determined using a novel and automated assay. RESULTS: The mean serum total thiol and native thiol levels were significantly lower in patients with PEX syndrome compared to healthy controls (p = 0.001). The mean serum disulfide level was significantly higher in patients with PEX syndrome compared to healthy controls (p = 0.023). The serum native thiol/disulfide ratio was lower in patients with PEX syndrome compared to healthy subjects (16 ± 10.1 vs 22.3 ± 11.5, respectively, p = 0.014). CONCLUSION: Our findings provide evidence that the dynamic native thiol/disulfide ratio is lower in PEX syndrome, which shows a reduction in the natural cell reductive capacity reservoir.
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