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  • Title: Differences in antimicrobial susceptibility of pigmented and unpigmented colonial variants of Mycobacterium avium.
    Author: Stormer RS, Falkinham JO.
    Journal: J Clin Microbiol; 1989 Nov; 27(11):2459-65. PubMed ID: 2808669.
    Abstract:
    Unpigmented colonial variants were isolated from pigmented Mycobacterium avium isolates recovered from patients with acquired immunodeficiency syndrome and the environment. The variants were interconvertible: the rate of transition from unpigmented to pigmented type was 4.0 x 10(-5) variants per cell per generation. The unpigmented variants were more tolerant to antibiotics, especially beta-lactams, and Cd2+ and Cu2+ salts than were their pigmented parents. Both pigmented and unpigmented variants of the strains produced beta-lactamase, although beta-lactamase did not appear to be a determinant of beta-lactam susceptibility. Pigmented variants grew more rapidly in a number of commonly used mycobacterial media, were more hydrophobic, and had higher carotenoid contents than their unpigmented segregants.
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