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  • Title: Herpes Simplex Encephalitis Complicated by Cerebral Hemorrhage during Acyclovir Therapy.
    Author: Harada Y, Hara Y.
    Journal: Intern Med; 2017; 56(2):225-229. PubMed ID: 28090058.
    Abstract:
    Herpes simplex encephalitis (HSE) can be complicated by adverse events in the acute phase. We herein present the case of a 71-year-old woman with HSE complicated by cerebral hemorrhage. She presented with acute deterioration of consciousness and fever and was diagnosed with HSE based on the detection of herpes simplex virus-1 in the cerebrospinal fluid by a polymerase chain reaction. The cerebral hemorrhage developed during acyclovir therapy; however, its diagnosis was delayed for 2 days. After the conservative treatment of the cerebral hemorrhage, the patient made a near-complete recovery. Cerebral hemorrhage should be considered as an acute-phase complication of HSE.
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