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  • Title: Synthesis of novel oleanolic acid and ursolic acid in C-28 position derivatives as potential anticancer agents.
    Author: Tian T, Liu X, Lee ES, Sun J, Feng Z, Zhao L, Zhao C.
    Journal: Arch Pharm Res; 2017 Apr; 40(4):458-468. PubMed ID: 28101738.
    Abstract:
    A series of nitrogen-containing derivatives of oleanolic acid and ursolic acid were prepared by a modification at C-28 position via esterification with 2-hydroxyacetic acid followed by amidation with amines, such as piperazine, N-methylpiperazine, and alkane-1, 2-diamines, alkane-1, 4-diamines, alkane-1, 6-diamines. In vitro antiproliferative activities of the compounds prepared towards MCF-7, Hela and A549 cell lines were evaluated by a MTT method to show that OA-5a, OA-5b, OA-5c and UA-5a showed somewhat improved antiproliferative activities against MCF-7, Hela and A549 cells comparing to that of the positive control, gefitinib.
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