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  • Title: Effect of D-galactosamine on blood clearance of 99mTc-phytate in rats.
    Author: Shibata H, Hisano T.
    Journal: J Toxicol Sci; 1989 Aug; 14(3):205-13. PubMed ID: 2810402.
    Abstract:
    The effect of D-galactosamine (GalN) on the blood clearance of 99mTc-phytate (99mTc-P) in rats was examined, and the blood clearance test of 99mTc-P was compared with the cases of serum transaminase and bilirubin test. Serum transaminase and bilirubin levels in rats increased dose-dependantly after GalN administration. The disappearance rate of 99mTc-P from blood decreased with the increase in dose of GalN and with the passage of time after the GalN administration. Changes of the blood clearance of 99mTc-P after GalN treatment in rats may be influenced by the disorder in the hepatocytes and the alteration of the liver reticuloendothelial system phagocytic function. The blood clearance test of 99mTc-P in rats showed a sensitive reaction for the acute hepatic dysfunction induced by GalN equally to or higher than the serum transaminase and bilirubin test.
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