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  • Title: A label-free electrochemical immunosensor based on a new polymer containing aldehyde and ferrocene groups.
    Author: Zhang X, Shen Y, Zhang Y, Shen G, Xiang H, Long X.
    Journal: Talanta; 2017 Mar 01; 164():483-489. PubMed ID: 28107962.
    Abstract:
    In this work, a novel and convenient strategy for synthesis of a well-defined polymer containing both aldehyde and ferrocene functional groups by grafting 4-hydroxybenzaldehyde and ferrocenecarboxylhydrazide onto linear poly (vinylbenzyl chloride) was developed. The designed polymer film (polymer CAF) could be used as a new support matrix for fabrication of a label-free electrochemical immunosensor with high sensitivity, good stability and repeatability. With human IgG as an analyte model, the proposed electrochemical immunosensor showed a linear concentration range from 0.1 to 20ngmL-1 with a detection limit of 0.07ngmL-1 (S/N=3). Moreover, interfering proteins including HSA, IgM, and IgE were added into the analyte, the developed immnnosensor can detect human IgG with high specificity.
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