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  • Title: [Anatomical study of the fibrosing action of Corynebacterium parvum in malignant pleural effusion].
    Author: Foresti V, Scolari N, Villa A, Parisio E.
    Journal: Minerva Med; 1989 Oct; 80(10):1069-72. PubMed ID: 2812462.
    Abstract:
    Intrapleural injection of Corynebacterium parvum (CBP) has recently been used for the treatment of recurrent neoplastic pleural effusions and its mechanism of action has been suggested to be either a local fibrosis-stimulating effect or immunostimulation. The case is reported of a patient with pleuritis secondary to metastases of mammary carcinoma, treated with CBP plus methylprednisolone, who died five days after the treatment because of an acute myocardial infarction. The pathologic examination showed fibrinous pleuritis with an interconnecting network between the visceral and parietal pleura.
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