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  • Title: [CRISPR-Cas system as molecular scissors for gene therapy].
    Author: Heinz GA, Mashreghi MF.
    Journal: Z Rheumatol; 2017 Feb; 76(1):46-49. PubMed ID: 28124743.
    Abstract:
    Since the discovery of the CRISPR-Cas system as the adaptive immune system of prokaryotes, the underlying mechanism has proven to be a precise molecular tool for the targeted editing of genetic information in various cell types. By using the CRISPR-Cas9 system DNA sequences can be cut out at any site in the genome and changed in a sequence-specific manner. In the long term this provides the opportunity to cure diseases caused by gene mutations.
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