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  • Title: Presynaptic muscarinic receptors in guinea pig superior cervical ganglion.
    Author: Capuzzo A, Borasio PG, Fabbri E.
    Journal: Neurosci Lett; 1989 Sep 25; 104(1-2):88-92. PubMed ID: 2812539.
    Abstract:
    This study characterizes the presynaptic muscarinic cholinergic receptors associated with the modulation of the electrically-evoked acetylcholine output from guinea pig superior cervical ganglion preincubated with [3H]choline. The M1-selective agonist pilocarpine had no effect while carbachol and oxotremorine strongly decreased the evoked outflow of tritium. Atropine increased such evoked release of [3H]acetylcholine whereas the M1-selective antagonist pirenzepine was ineffective. Moreover, atropine but not pirenzepine antagonized the inhibitory effect of carbachol. These results suggest that the guinea-pig superior cervical ganglion is equipped with presynaptic inhibitory muscarinic receptors of the M2 subtype.
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