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  • Title: [Treatment of vaso-occlusive crisis of sickle-cell disease with pentoxifylline].
    Author: Clerc M, Doh-Egueli D, Chapuis F, Durin A, Bertrand Y, Souillet G, Philippe N.
    Journal: Pediatrie; 1989; 44(7):577-81. PubMed ID: 2812975.
    Abstract:
    Sickle-cell disease is usually complicated by vaso-occlusive attacks. A review of the case-histories of 26 patients permitted an analysis of 92 severe attacks. We compared the outcome of 52 attacks treated with hyperhydration associated with a modifying erythrocyte membrane agent (pentoxifylline), with 40 attacks treated with hyperhydration and other drugs. This result compares well the current knowledge of the rheologic mechanisms involved in vaso-occlusive attacks of sickle-cell disease.
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