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  • Title: Isolation and hypoglycemic activity of trichosans A, B, C, D, and E: glycans of Trichosanthes kirilowii roots.
    Author: Hikino H, Yoshizawa M, Suzuki Y, Oshima Y, Konno C.
    Journal: Planta Med; 1989 Aug; 55(4):349-50. PubMed ID: 2813568.
    Abstract:
    The non-dialyzable portion of the water extract of the Oriental crude drug "karokon", the roots of Trichosanthes kirilowii, was found to reduce the plasma glucose level in mice. Activity-guided fractionation of this non-dialyzable portion led to the isolation of five glycans termed as trichosans A, B, C, D and E, showing hypoglycemic actions in normal mice. The main glycan, trichosan A, also exhibited activity in alloxan-induced hyperglycemic mice.
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