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  • Title: Bioactive steroids and sorbicillinoids isolated from the endophytic fungus Trichoderma sp. Xy24.
    Author: Zhao JL, Zhang M, Liu JM, Tan Z, Chen RD, Xie KB, Dai JG.
    Journal: J Asian Nat Prod Res; 2017 Oct; 19(10):1028-1035. PubMed ID: 28145126.
    Abstract:
    A new steroid glucoside (1), along with nine known steroids (2-10) and four known sorbicillinoids (11-14), were isolated from the endophytic fungus Trichoderma sp. Xy24. Their structures were elucidated on the basis of spectroscopic data analyses and by comparison with reported data. Compounds 3, 5-7, 9, 10, and 13 exhibited significant inhibitory effects on HIV-1 virus with IC50 values ranging 1.9-9.3 μM; compounds 10, 13, and 14 showed potent inhibitory activity on LPS-induced NO production in BV2 microglia cells with inhibitory rates of 108.2, 100, and 75.1% at 10 μM, respectively. In addition, compound 10 displayed moderate cytotoxicity against BCG823 and HePG2 cell lines with IC50 values of 11.1 and 17.7 μM, respectively.
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