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  • Title: Posttranscriptional regulation of Galectin-3 by miR-128 contributes to colorectal cancer progression.
    Author: Lu W, Wang J, Yang G, Yu N, Huang Z, Xu H, Li J, Qiu J, Zeng X, Chen S, Li N, Liu H.
    Journal: Oncotarget; 2017 Feb 28; 8(9):15242-15251. PubMed ID: 28146425.
    Abstract:
    Here we demonstrated that Galectin-3 protein level was frequently up-regulated in colorectal cancer (CRC) cells and tissues. Galectin-3 up-regulation correlated with CRC progression and predicted a shorter overall survival of CRC patients. Galectin-3 overexpression attenuated the chemo-sensitivity of cancer cells, but enhanced the potential invasiveness. To explore the mechanism for Galectin-3 dysregulation, we found that miR-128 level was frequently down-regulated in CRC and negatively correlated with Galectin-3 level. Using bioinformatics analysis and experimental validation, we showed that miR-128 could directly target Galectin-3 to repress its protein level. MiR-128 decrease associated with CRC progression and predicted a worse overall survival of CRC patients. Ectopic miR-128 expression enhanced the chemo-sensitivity of CRC cells in vitro and in vivo, and inhibited the potential invasiveness. Galectin-3 expression impaired the cancer suppressive effects of miR-128. These data highlighted the role of miR-128/Galectin-3 axis in colorectal cancer.
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