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  • Title: Further brominated polyacetylenes with pancreatic lipase inhibitory activity from Chinese marine sponge Xestospongia testudinaria.
    Author: Yang M, Liang LF, Wang T, Wang HY, Liu HL, Guo YW.
    Journal: J Asian Nat Prod Res; 2017 Jul; 19(7):732-737. PubMed ID: 28152617.
    Abstract:
    A new brominated polyacetylene, xestonariene I (1), along with three known related analogues (2-4), was obtained from Chinese marine sponge Xestospongia testudinaria. Its structure was determined on the basis of detailed spectroscopic analysis and by comparison with literature data. Compound 4 exhibited significant inhibitory activity against pancreatic lipase, which plays a key role in preventing obesity, with an IC50 value of 0.61 μM, being comparable to that of the positive control orlistat (IC50 = 0.78 μM).
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