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  • Title: [Changes in the blood coagulation and fibrinolysis systems in newborn infants with infections and normal and low birth weight].
    Author: Grygalewicz J, Obermajer-Kamieńska E, Kozierowska T.
    Journal: Wiad Lek; 1989 Jan 15; 42(2):87-93. PubMed ID: 2815742.
    Abstract:
    The blood clotting and fibrinolysis systems were examined in 97 newborns hospitalized for diseases caused by infection. Two groups were isolated on the basis of differences in birth weight: group A with normal birth weight and group B with low birth weight. The observation of changes developing in the blood clotting and fibrinolysis systems during infection was confirmed. Differences were noted in the response of blood clotting system between group A and B. In newborns with low birth weight (group B) plasma clotting time was more frequently prolonged (especially the time of prothrombin plasma clotting), and prolongation was noted also in the plasma euglobulin lysis time. Less frequently, however, a positive ethanol test and reactions in the form of increased fibrinogen concentration and platelet count rise were found. These differences may suggest a more profound immaturity of the studied newborns with low birth weight, and their greater susceptibility to infection-related coagulopathy.
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