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  • Title: The miscibility of milk sphingomyelin and cholesterol is affected by temperature and surface pressure in mixed Langmuir monolayers.
    Author: Cheng K, Ropers MH, Lopez C.
    Journal: Food Chem; 2017 Jun 01; 224():114-123. PubMed ID: 28159245.
    Abstract:
    The miscibility of milk sphingomyelin (milk-SM) and cholesterol was investigated in this study. The effect of different physical states of milk-SM on its interactions with cholesterol was determined by the recording of isotherms of compression of Langmuir films for temperatures above and below the gel to Lα phase transition of milk-SM (Tm∼34°C). For T=15°C<Tm, the liquid expanded (LE) to liquid condensed (LC) phase transition of milk-SM monolayers was observed at surface pressures of 10-15mN/m. For T=43°C>Tm, the milk-SM molecules were in a LE phase regardless of the surface pressure applied. A phase diagram pressure - milk-SM/cholesterol composition was established. This study demonstrated that both temperature and surface pressure affected the miscibility between the milk-SM and cholesterol. The strongest attractive forces (i.e. condensing effect) were identified for 30mol% cholesterol when the milk-SM was in the LE phase state.
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