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  • Title: A novel monoclonal antibody against the von Willebrand Factor A2 domain reduces its cleavage by ADAMTS13.
    Author: Zhang L, Su J, Shen F, Ma Z, Zhao Y, Xia L, Ruan C.
    Journal: J Hematol Oncol; 2017 Feb 06; 10(1):42. PubMed ID: 28166803.
    Abstract:
    We developed a novel murine monoclonal antibody (mAb) against the C-terminal α-helix of the human von Willebrand factor A2, designated SZ-179. We showed that SZ-179 inhibited the interactions between VWF and ADAMTS13 and prevented the degradation of high molecular weight VWF multimers. Importantly, SZ-179 reduced the proteolysis of VWF-R1597W mutant by rADAMTS13 dose-dependently under native conditions. Our findings reveal a potential therapeutic target for bleeding disorders.
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