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  • Title: Post-transfusion purpura and isoimmune neonatal thrombocytopenia in the same family.
    Author: Cobos E, Gandara DR, Geier LJ, Kirmani S.
    Journal: Am J Hematol; 1989 Nov; 32(3):235-6. PubMed ID: 2816919.
    Abstract:
    Post-transfusion purpura and isoimmune neonatal thrombocytopenia are rare and unusual syndromes leading to severe thrombocytopenia. In both disorders the PLA1 platelet antigen is involved in the pathogenesis. A 41-year-old woman with an obstetrical history of isoimmune neonatal thrombocytopenia in two of her children developed post-transfusion purpura following a transfusion of packed red blood cells. Despite the apparent link in these two disorders associated with the PLA1 platelet antigen, this is the first reported case of post-transfusion purpura and isoimmune neonatal thrombocytopenia occurring in the same family.
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