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  • Title: Studies on the formation and stability of isoindoles derived from amino acids, o-phthalaldehyde and N-acetyl-L-cysteine.
    Author: García Alvarez-Coque MC, Medina Hernández MJ, Villanueva Camañas RM, Mongay Fernández C.
    Journal: Anal Biochem; 1989 Jul; 180(1):172-6. PubMed ID: 2817340.
    Abstract:
    A kinetic-spectrophotometric study is performed on the formation and degradation of the isoindole derivatives of amino acids with o-phthalaldehyde and N-acetyl-L-cysteine. The experimental and structural factors which affect the formation and stability of the compounds are considered, and the results are compared with those obtained for mercaptoethanol. N-Acetyl-L-cysteine derivatives are highly stable, not requiring a strict control of the time of reaction as in the case of mercaptoethanol.
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