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  • Title: Semi-rigid mitral annuloplasty rings improve myocardial stress adaptation compared to rigid rings: insights from in vitro and in vivo experimental evaluation.
    Author: Skov SN, Røpcke DM, Tjørnild MJ, Ilkjær C, Rasmussen J, Nygaard H, Jensen MO, Nielsen SL.
    Journal: Eur J Cardiothorac Surg; 2017 May 01; 51(5):836-843. PubMed ID: 28175268.
    Abstract:
    OBJECTIVES: Investigate myocardial stress adaptation and remodelling capacity of a rigid and semi-rigid mitral annuloplasty ring. METHODS: The annuloplasty rings were characterized in vitro in a mechanical setup with tensile and compressive forces from 0 to 3 N. The rings were tested with and without fixation of the ring to imitate the effect of annular implantation. In vivo measurements were performed with 21 porcine animals randomized into: A no ring group, a rigid ring group (Classic Annuloplasty Ring TM , Edwards Lifesciences) and a semi-rigid ring group (Physio I Annuloplasty Ring, Edwards Lifesciences). The rings were implanted together with a force transducer and sonomicrometry was used for geometry measurements. RESULTS: The flexibility range of the semi-rigid ring was 7.6 and 2.4 mm in the septal-lateral and commissural direction, respectively. With fixation the flexibility was reduced to 1.0 and 0.6 mm, similar to the rigid ring without fixation. In vivo measurements indicated that the rigid and semi-rigid rings equally restrict the annular movement. Septal-lateral flexibility of the semi-rigid ring was not observed. Both rings induced force absorption in the ring and sutures due to the annular fixation. The absorbed forces were significantly lower for the semi-rigid ring in the posterior segment and septal-lateral direction. CONCLUSIONS: This study demonstrates the importance of correct fixation when characterizing annuloplasty rings. The annular movement of the semi-rigid ring was similar to the rigid ring when implanted at the mitral annulus as confirmed in vitro . Despite this the semi-rigid ring demonstrated a favourable stress adaptation which could potentially decrease the risk of ring dehiscence.
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