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  • Title: Copper (II) induced radiosensitization of thymine.
    Author: Bhattacharyya SN, Mandal PC, Chakraborty S.
    Journal: Anticancer Res; 1989; 9(4):1181-4. PubMed ID: 2817799.
    Abstract:
    An aqueous solution of thymine (2 x 10(-3) M, pH 5.6) was irradiated with 60Co gamma-rays in the absence and in the presence of CuSO4 (5 x 10(-4) M) under different conditions. In argon and N2O saturated solutions, the presence of CuSO4 increased the radiosensitivity of thymine to a greater extent, while the product distribution was changed. Thus in the presence of CuSO4 the formation of dimeric products was prevented and the yields of cis-thymine glycol and 5-hydroxymethyl uracil were greatly increased. The sensitized degradation was suggested to be due to the oxidation of the transient hydroxyl adducts of thymine by copper ions.
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