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  • Title: Total Synthesis of GKK1032A2 via Direct 13-Membered Macrocyclization Using a Nucleophilic Aromatic Substitution of an (η6 -Arene)Chromium Complex.
    Author: Sugata H, Inagaki K, Ode T, Hayakawa T, Karoji Y, Baba M, Kato R, Hasegawa D, Tsubogo T, Uchiro H.
    Journal: Chem Asian J; 2017 Mar 16; 12(6):628-632. PubMed ID: 28181417.
    Abstract:
    The first enantioselective total synthesis of GKK1032A2 has been achieved. The key step is a direct construction of the highly strained 13-membered macrocycle of GKK1032A2 by an intramolecular nucleophilic aromatic substitution (SN Ar) reaction. This is the first successful example of construction of a macrocycle with an aryl ether linkage utilizing an intramolecular SN Ar reaction of an (η6 -arene)chromium complex.
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