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  • Title: Diamond-based electrochemical aptasensor realizing a femtomolar detection limit of bisphenol A.
    Author: Ma Y, Liu J, Li H.
    Journal: Biosens Bioelectron; 2017 Jun 15; 92():21-25. PubMed ID: 28182974.
    Abstract:
    In this study, we designed and fabricated an electrochemical impedance aptasensor based on Au nanoparticles (Au-NPs) coated boron-doped diamond (BDD) modified with aptamers, and 6-mercapto-1-hexanol (MCH) for the detection of bisphenol A (BPA). The constructed BPA aptasensor exhibits good linearity from 1.0×10-14 to 1.0×10-9molL-1. The detection limitation of 7.2×10-15molL-1 was achieved, which can be attributed to the synergistic effect of combining BDD with Au-NPs, aptamers, and MCH. The examine results of BPA traces in Tris-HCl buffer and in milk, UV spectra of aptamer/BPA and interference test revealed that the novel aptasensors are of high sensitivity, specificity, stability and repeatability, which could be promising in practical applications.
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