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  • Title: Long non-coding RNA in glioma: signaling pathways.
    Author: Shi J, Dong B, Cao J, Mao Y, Guan W, Peng Y, Wang S.
    Journal: Oncotarget; 2017 Apr 18; 8(16):27582-27592. PubMed ID: 28187439.
    Abstract:
    Glioma is regarded as the most prevalent malignant carcinoma of the central nervous system. Thus, the development of new therapeutic strategies targeting glioma is of significant clinical importance. Long non-coding RNAs (lncRNAs) are functional RNA molecules without a protein-coding function and are reportedly involved in the initiation and progression of glioma. Dysregulation of lncRNAs in glioma is due to activation of several signaling pathways, such as the BRD4-HOTAIR-β-catenin/PDCD4, p53-Hif-H19/IGF2 and CRNDE/mTOR pathways. Furthermore, microRNAs (miRNAs) such as miR-675 also interact with lncRNAs in glioma. Thus, exploring the mechanisms by which lncRNA control processes will be instrumental for devising new effective therapies against glioma.
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