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  • Title: Highly selective optical and reversible dual-path chemosensor for cyanide detection and its application in live cells imaging.
    Author: Keshav K, Torawane P, Kumar Kumawat M, Tayade K, Sahoo SK, Srivastava R, Kuwar A.
    Journal: Biosens Bioelectron; 2017 Jun 15; 92():95-100. PubMed ID: 28189907.
    Abstract:
    A new biocompatible fluorescent receptor 1 was synthesized by conjugating diaminomaleonitrile (DMN) with benzothiazole unit, and characterized by single X-ray. In DMF/water (1:1, v/v), the receptor 1 showed a selectivity turn-on fluorescence at 517nm in the presence of CN-. Receptor 1 showed a detection limit down to 0.16µM without any interference from other tested anions. The reversibility and reusability of 1 for the detection of CN- ion was also tested for five cycles indicating the probe 1 could be used in a reversible manner. Importantly, the receptor 1 showed excellent cells viability and was successfully applied for the detection of CN- in live mouse fibroblast cells L929 cells.
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