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  • Title: Edible solid lipid nanoparticles (SLN) as carrier system for antioxidants of different lipophilicity.
    Author: Oehlke K, Behsnilian D, Mayer-Miebach E, Weidler PG, Greiner R.
    Journal: PLoS One; 2017; 12(2):e0171662. PubMed ID: 28192494.
    Abstract:
    Ferulic acid (FA) and tocopherol (Toc) loaded solid lipid nanoparticles (SLN) were prepared by a hot homogenisation method. The particle size distribution, zeta potential and melting behaviour of the SLN as well as the stability, encapsulation efficiency and radical scavenging activity of FA and Toc in the SLN were analysed. The different formulations containing up to 2.8 mg g-1 of FA or Toc were stable during at least 15 weeks of storage at room temperature. Despite partial degradation and / or release of FA and Toc during storage, significant radical scavenging activity was maintained. DSC measurements and radical scavenging tests after different time periods revealed that the re-structuring of the lipid matrix was connected to the enhanced antioxidant activity of Toc but did not affect the activity of FA.
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