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  • Title: Alpha adrenoceptor modulation of the jaw-opening reflex.
    Author: Curtis AL, Marwah J.
    Journal: Neuropharmacology; 1987 Jul; 26(7A):649-55. PubMed ID: 2819761.
    Abstract:
    In the present study, the nature, role and location of the alpha-adrenoceptors, modulating the tooth pulp stimulation (TPS)-evoked jaw-opening reflex (JOR), was investigated. Clonidine, a lipophilic alpha 2-adrenoceptor agonist, rapidly, reversibly and significantly elevated the threshold of the digastric electromyogram (dEMG) evoked by tooth pulp stimulation which was antagonized by yohimbine or piperoxane (two alpha 2-adrenoceptor antagonists) but not by prazosin (an alpha 1-adrenoceptor antagonist). 4-Hydroxyclonidine and ST-91 non lipophilic alpha 2 adrenoceptor agonists, were ineffective on the tooth pulp stimulation-evoked threshold of the digastric electromyogram. Clonidine was ineffective upon digastric muscle stimulation (DMS)-evoked threshold of the digastric electromyogram of the curarized digastricus and mylohyoid (motor) nerve stimulation (MNS)-evoked digastric EMG. It is concluded that modulation by clonidine of the tooth pulp stimulation-evoked jaw-opening reflex is devoid of a peripheral efferent component and that such modulation is predominantly expressed through interactions with centrally located alpha 2 adrenoceptors.
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