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  • Title: Rapid and Complete Surface Modification with Strain-Promoted Oxidation-Controlled Cyclooctyne-1,2-Quinone Cycloaddition (SPOCQ).
    Author: Sen R, Escorihuela J, van Delft F, Zuilhof H.
    Journal: Angew Chem Int Ed Engl; 2017 Mar 13; 56(12):3299-3303. PubMed ID: 28198134.
    Abstract:
    Strain-promoted oxidation-controlled cyclooctyne-1,2-quinone cycloaddition (SPOCQ) between functionalized bicyclo[6.1.0]non-4-yne (BCN) and surface-bound quinones revealed an unprecedented 100 % conjugation efficiency. In addition, monitoring by direct analysis in real time mass spectrometry (DART-MS) revealed the underlying kinetics and activation parameters of this immobilization process in dependence on its microenvironment.
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