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  • Title: Changes in cardiac output during the development of renal hypertension in sodium-depleted dogs.
    Author: Davis JO, Stephens GA, Freeman RH, Deforrest JM.
    Journal: Clin Sci Mol Med Suppl; 1978 Dec; 4():221s-223s. PubMed ID: 282055.
    Abstract:
    1. Chronic renovascular hypertension developed in uninephrectomized, sodium-depleted dogs in association with a decrease in cardiac output. 2. With sodium and volume repletion of these animals, cardiac output returned to normal but the high level of arterial pressure was unchanged; consequently, the peripheral arterioles dilated. 3. These observations provide evidence against the theory of whole-body autoregulation.
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