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  • Title: Functional interleukin 2 receptors on B cells lacking Tac antigens.
    Author: Tanaka T, Saiki O, Doi S, Hatakeyama M, Doi T, Kono T, Mori H, Fujii M, Sugamura K, Negoro S.
    Journal: Eur J Immunol; 1987 Sep; 17(9):1379-82. PubMed ID: 2820752.
    Abstract:
    Human B lymphoblastoid line, SKW 6-4, cells were induced to IgM-secreting cells by high concentrations of interleukin 2 (IL 2). These cells were found to be unreactive with anti-Tac antibody and did not express mRNA detectable for Tac antigen. In Scatchard plot analysis, low-affinity IL 2-binding sites were found on SKW 6-4 cells. Moreover, analysis of the IL 2-binding molecules revealed ones (molecular weight 70,000 and 75,000) distinct from Tac antigen. It is conceivable that IL 2 exerts its effect through its interaction with these novel IL 2-binding molecules in SKW 6-4 cells.
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