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  • Title: Inhibition of non-adrenergic transmission in the rat vas deferens by prazosin.
    Author: Ebong OO, Zar MA.
    Journal: Afr J Med Med Sci; 1987 Jun; 16(2):103-7. PubMed ID: 2821775.
    Abstract:
    Isolated preparations of rat vas deferens were induced to contract by neurogenic and non-neurogenic stimuli, and the effect of prazosin on these contractions was investigated. Prazosin (24 microM) exerted a profound inhibitory effect on neurogenic contractions and had no significant effect on non-neurogenic contractions. These experiments indicate that prazosin is capable of interacting with the neurotransmission processes in the vas deferens to produce inhibition of transmission.
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