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  • Title: Short Total Synthesis of (±)-γ-Lycorane by a Sequential Intramolecular Acylal Cyclisation (IAC) and Intramolecular Heck Addition Reaction.
    Author: Monaco A, Szulc BR, Rao ZX, Barniol-Xicota M, Sehailia M, Borges BM, Hilton ST.
    Journal: Chemistry; 2017 Apr 06; 23(20):4750-4755. PubMed ID: 28217842.
    Abstract:
    An intramolecular acylal cyclisation (IAC) approach to the synthesis of a range of bicyclic heterocycles is reported. As an example of the utility of the IAC reaction, the methodology was applied in a protecting-group-free five-step total synthesis of (±)-γ-lycorane, incorporating a new intramolecular Heck addition reaction to generate the pentacyclic core structure of the natural product in good yield.
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