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  • Title: Expression of Tac antigen by non-Hodgkin's lymphomas.
    Author: Weiss LM, Michie SA, Medeiros LJ, Strickler JG, Garcia CF, Warnke RA.
    Journal: Am J Clin Pathol; 1987 Oct; 88(4):483-5. PubMed ID: 2821794.
    Abstract:
    Anti-Tac is a monoclonal antibody that appears to recognize the interleukin-2 receptor. With the use of a frozen-section immunoperoxidase technic, a large series of non-Hodgkin's lymphomas were investigated for the presence of Tac-antigen on neoplastic cells. Approximately one-fourth of cases expressed the Tac antigen, including 27% of B-lineage lymphomas, 6% of the T-lineage lymphomas, and three of four cases of Ki-1-expressing lymphoma. The B-lineage lymphomas with the highest incidence of Tac antigen expression were the large cell lymphomas, both diffuse and follicular, where about one-half of cases expressed the Tac antigen. All major categories of lymphoma expressed Tac except plasma-cytoma/myeloma, small noncleaved cell (Burkitt's and non-Burkitt's), and lymphoblastic malignancies.
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