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  • Title: Chemical Constituents and Anti-inflammatory Principles from the Fruits of Forsythia suspensa.
    Author: Kuo PC, Hung HY, Nian CW, Hwang TL, Cheng JC, Kuo DH, Lee EJ, Tai SH, Wu TS.
    Journal: J Nat Prod; 2017 Apr 28; 80(4):1055-1064. PubMed ID: 28218000.
    Abstract:
    Fifty compounds were isolated from the fruits of Forsythia suspensa, including 13 new compounds characterized as eight new diterpenoids (1-8), three new lignans (9-11), a new iridoid (12), and a new triterpenoid (13). Their structures were established on the basis of spectroscopic and spectrometric analysis. Most of the isolated compounds were examined for their anti-inflammatory activity in vitro. The results showed that several compounds displayed significant inhibition of fMLP/CB-induced superoxide anion generation and elastase release, with IC50 values ranging from 0.6 ± 0.1 to 8.6 ± 0.8 μg/mL and from 0.8 ± 0.3 to 7.3 ± 1.1 μg/mL, respectively.
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